Two Drug Combo Slows Advanced Pancreatic Cancer


The combination of the novel drug TH-302 with the standard drug gemcitabine has shown early signs of delaying the worsening of cancer in patients with advanced pancreatic cancer, a Mayo Clinic-led study has found. This was evaluated using a measure termed progression-free survival (PFS). According to the results of a multi-center Phase II clinical trial, patients receiving the combination of gemcitabine and TH-302 demonstrated a progression-free survival of 5.6 months compared to 3.6 months in those patients who received gemcitabine alone.

The two-month delay in worsening of the cancer is considered significant given that the average survival of patients with advanced pancreatic cancer is only six to seven months.

Read more

By susanashephard | Posted in Cancer, Research | Tagged , , , , , | Leave a comment

Gene Targets Identified for New Non-invasive Colorectal Cancer Screening Test


American Association for Cancer Research

Journalists:  See bottom of this post for audio and video resources

Mayo Clinic researchers are close to developing a quick non-invasive test that can detect early stage colorectal cancer and precancerous polyps. The test uses a small sample of a patient’s stool to check for specific DNA changes, known as gene methylation, that occur as cancer develops. In a study, presented this week at the American Association for Cancer Research annual meeting, they identified two genes that are optimal targets for the test.

The stool test is currently being evaluated in a large multicenter study in the United States and Canada, involving 10,000 patients at more than 60 medical centers. If the test is approved by the Food and Drug Administration, it could become available to patients as early as mid-2013.

Mayo Clinic and Dr. Ahlquist have a financial interest in the technology.

Click here to view the news release.

Journalists: The following audio and video clips with Dr. Ahlquist are available for download and use in your stories.

Broll:    MOV

Issues with Screenings:   MOV   MP3

Stool Test Explained:    MOV   MP3

Specificity:   MOV    MP3

Study Findings:   MOV    MP3

Future of Test:   MOV   MP3

Below is an edited youtube video of Dr. Ahlquist discussing this latest study.  You may embed it with your stories.

By joedangor | Posted in Cancer, Gastroenterology, Research | Tagged , , , , | Comments (1)

Nutritional Supplement Works Against Some Pancreatic Cancer Cells in Mice


American Association for Cancer Research

Journalists:  See bottom of this post for video and audio resources

The dietary supplement gamma-linolenic acid can inhibit the growth of a subset of pancreatic cancer cells and selectively promote cancer cell death in mice, say Mayo Clinic researchers. The supplement, a fatty acid also known as GLA, worked particularly well when combined with the chemotherapy drug gemcitabine, the researchers say. The findings were presented today by Mayo Clinic pathologist Ruth Lupu, Ph.D., at the American Association for Cancer Research conference.

Click here to view the news release.

Journalists:  The following video and audio clips with Dr. Lupu are available for download and use in your stories:

Background:   MOV    MP3

Study Overview:  MOV    MP3

Study Findings:   MOV    MP3

Chemotherapy Combo:   MOV    MP3

Next Steps:   MOV   MP3

Below is an edited youtube video of Dr. Lupu discussing the study,  It may be embedded into your stories.

By joedangor | Posted in Cancer, Research | Tagged , , , | Comments (2)

Emerging Fungal Infection in Southwest Mimics Cancer


A fungal infection of the gastrointestinal tract that mimics cancer and inflammatory bowel disease appears to be emerging in the Southwestern United States and other desert regions, according to Mayo Clinic researchers in Arizona investigating the disease.  The invasive fungus, Basidiobolus ranarum, is typically found in the soil, decaying organic matter and the gastrointestinal tracts of fish, reptiles, amphibians, and bats.

“The exact mode of acquisition of this gastrointestinal infection is unclear, although consumption of contaminated food or dirt is the favored hypothesis,” says lead author H.R. Vikram, M.D., consultant, Division of Infectious Diseases, at Mayo Clinic, where seven of the 19 U.S. cases studied were treated.  “The infection is still considered so rare that no one had put together a complete description.” He adds that more study needs to be done to determine how this infection is contracted, what underlying diseases might predispose patients to this infection and how best to treat it. He emphasizes that early recognition is key to successful treatment. Read more

By susanashephard | Posted in Infectious Diseases | Tagged , , , , , , , | Comments (1)

Tick Alert: Mayo Clinic Expert Offers Tips for Avoiding, Spotting Tick-Borne Diseases


Deer tick

Spring has only just arrived, but tick season is well under way. Physicians are seeing new cases of tick-borne illness several weeks earlier than usual, likely because a mild winter in much of the country made life easier for ticks and their offspring. That means it’s time for gardeners, hikers, pet owners and others who spend time outdoors to take steps to protect themselves — and to watch for symptoms of tick-borne illness if they do come in contact with the tiny bloodsuckers.

“We’ve already started getting positives for tick-borne disease such as Lyme disease,
anaplasmosis and babesiosis,” says Bobbi Pritt, M.D., a Mayo Clinic microbiologist and director of the Clinical Parasitology and Virology Laboratories. That is a month or two earlier than normal for Minnesota and other states with unusually warm weather in recent months are likely seeing the same. Read more

By sharontheimer | Posted in Infectious Diseases | Tagged , , , , , , , | Comments (3)

Skin Cancer News


Journalists:  See bottom of post for audio and video resources

Mayo Clinic Study Finds Dramatic Rise in Skin Cancer in Young Adults
Researchers speculate indoor tanning bed use, childhood sunburns are key culprits

Even as the rates of some cancers are falling, Mayo Clinic is seeing an alarming trend: the dramatic rise of skin cancer, especially among people under 40. According to a study by Mayo Clinic researchers published in the April issue of Mayo Clinic Proceedings, the incidence of melanoma has escalated, and young women are the hardest hit.  

“We anticipated we’d find rising rates, as other studies are suggesting, but we found an even higher incidence than the National Cancer Institute had reported using the Surveillance, Epidemiology and End Result database, and in particular, a dramatic rise in women in their 20s and 30s,” says lead investigator Jerry Brewer, M.D., a Mayo Clinic dermatologist. Researchers conducted a population-based study using records from the Rochester Epidemiology Project, a decades-long database of all patient care in Olmsted County, Minn. They looked for first-time diagnoses of melanoma in patients 18 to 39 from 1970 to 2009. The study found the incidence of melanoma increased eightfold among young women and fourfold among young men. The lifetime risk of melanoma is higher in males than females, but the opposite is true in young adults and adolescents, Dr. Brewer says.

Researchers also found mortality rates from the disease have improved over the years, likely due to early detection of skin cancer and prompt medical care.

 “People are now more aware of their skin and of the need to see a doctor when they see changes,” Dr. Brewer says.  “As a result, many cases may be caught before the cancer advances to a deep melanoma, which is harder to treat.”  

The researchers speculate that the use of indoor tanning beds is a key culprit in the rising cancer rate in young women.

Janey Helland, of Mapleton, Minn., didn’t think twice when tanning in high school and college.

“I used tanning beds to get ready for homecoming and prom,” she says. “In college, I tanned before a trip to Barbados because I didn’t want to get sunburned.” At age 21, Helland noticed an abnormal spot on her leg. It was melanoma, and the diagnosis changed Helland’s life. “I really didn’t know what my future was going to look like, or if I’d even have one.” 

Two years later, she is cancer-free and dedicated to educating others. “I would advocate that it’s better to be safe than sorry,” she says.  “My advice is to educate yourself and research the risk factors.”

Childhood sunburns and ultraviolet exposure in adulthood may also contribute to melanoma development, the researchers say.

Journalists:   The following soundbites from Dr. Brewer are available for download and use in your stories:

Findings:   MOV   MP3

Study Significance:   MOV   MP3

Tanning Bed Effect:   MOV   MP3

You’re Not Immune:   MOV   MP3

Prevention:   MOV   MP3

By kelley luckstein | Posted in Cancer | Comments (8)

Mayo Clinic PCI Risk Score as Performance Metric for Interventional Cardiologists


Journalists:  See bottom of this post for audio and video resources.

A recent study conducted by Mayo Clinic focuses on predicting operator outcomes in coronary angioplasty procedures.

“We’ve been interested in prediction of outcomes after coronary angioplasty and stent procedures for some time,” says Mayo Clinic Cardiologist, Dr. Charanjit Rihal. “Almost ten years ago, we published a paper called ‘The Mayo Clinic Risk Score for Prediction of Adverse Events following Coronary Angioplasty and Stent Procedures’. We’ve since refined into the ‘New Mayo Clinic Risk Score’, which includes seven key variables that predict bad outcomes following PCI procedures.”

The study, which was presented at the 2012 ACC Annual Scientific Session & Expo, presents a novel application of the Mayo Clinic Risk Score to predict operator specific outcomes in coronary angioplasty procedures.

“We looked at the outcomes of over 8000 procedures performed by 21 Mayo Clinic interventional cardiologists as predicted by the Mayo Clinic Risk Score,” says Dr. Rihal. “On an individual basis, we were able to calculate the expected mortality and adverse event rate and compare that to the actual observed mortality and adverse event rate. We were able to show that in our clinical practice of PCI, this risk score was very useful as a performance measure.”

Journalists:  The following soundbites from Dr. Rihal are available for download and use in your stories.

Study Overview:   MOV   MP3

Study Findings:   MOV   MP3

Background on PCI:   MOV   MP3

Mayo Clinic Risk Score:   MOV   MP3

Takeaway Message:  MOV   MP3

Below is an edited youtube video of Dr. Rihal discussing the study.  You may embed this with your stories.

 

By Traci Klein | Posted in Cardiology & Cardiac Surgery | Tagged , , , | Leave a comment

ACC Reaction to Cheney Heart Transplant


Journalists:  See bottom of post for audio and video resources.

Speaking on behalf of the American College of Cardiology, at that groups annual meeting in Chicago, Dr. Mary Norine Walsh, medical director of the heart transplantation program at St. Vincent’s Heart Center of Indiana, shared her thoughts with reporters during an impromptu news conference regarding former vice president Dick Cheney’s heart transplant.

Journalists: The following soundbites from Dr. Walsh are available for download.

Broll:   MOV

What We Know:    MOV    MP3

Recovery:    MOV    MP3

Age At Transplant:   MOV   MP3

Risks:    MOV    MP3

By mayoclinic | Posted in Cardiology & Cardiac Surgery, Transplant | Tagged , , , , | Leave a comment

David Holmes, M.D., Reflects on the Past Year as President of ACC


Mayo Clinic cardiologist David R. Holmes, M.D., reflects back on his year as president of the American College of Cardiology (ACC). 

“It’s been a huge deal to be president of ACC,” said Dr. Holmes, “Cardiology has been incredibly good to me, and this was a chance to give back to the American and the global perspective on cardiovascular disease.”

“This has been an incredible journey in terms of trying to mold and trying to spread the new educational initiatives and to enhance the learning skills and learning messages that patients receive,” says Dr. Holmes

In addition to the learning initiatives, Dr. Holmes found the experience to be personally educating as well, saying, “I’ve learned a lot of things about medical care, broad global perspective of medical care, and non-communicable diseases worldwide.”

Dr. Holmes also fostered new relationships with colleagues during his time as ACC President.  “It’s been a great opportunity to involve other societies and an incredible opportunity to work with my cardiovascular surgeon colleagues.”

This year’s conference is being held in Chicago from March 24-27 and its convocation ceremony will feature the induction of incoming ACC president William A. Zoghbi, M.D., who is the William L. Winters endowed Chair of Cardiovascular Imaging at The Methodist DeBakey Heart & Vascular Center and director of the Cardiovascular Imaging Institute at the Methodist Hospital in Houston, Texas.

The video of Dr. Holmes can be found below:

By mayoclinic | Posted in Cardiology & Cardiac Surgery | Tagged , , , | Leave a comment

Obesity Risk Score to Predict Mortality in Patients with Coronary Artery Disease


Journalists:  See bottom of this post for audio and video resources.

A recent study co-authored by Mayo Clinic physicians and presented at the 2012 ACC Annual Scientific Session & Expo might change the way we assess obesity in individuals with heart disease.

This study included 15,000 coronary artery disease patients from 3 different continents, and was designed to learn the affect that distribution of body fat has on overall mortality risk.

The study found that individuals who were “skinny” according to BMI, but had an abnormal distribution of fat (waist larger than hips), were 4-5 times more likely to die long-term than individuals who were a little bit overweight, but had a normal distribution of fat (waist smaller than hips).

The study marks the first time that physicians have been able separate patients according to their mortality risk based solely on body weight and distribution of fat.

“We believe these findings might change the way we assess obesity in the clinical practice when we see individuals with heart disease,” says Dr. Francisco Lopez-Jimenez. “A single measurement, just weighing patients, is not enough to separate their risk of death by high, low, or very low.”

Journalists:  The following soundbites from Dr. Lopez-Jimenez are available for download and use in your stories:

Study Overview:   MOV   MP3

Study Findings:   MOV   MP3

Determining Risk Factors:   MOV   MP3

Implications:   MOV   MP3

Below is an edited youtube video of Dr. Lopez-Jimenez discussing the study that can be embedded with your stories.

By Traci Klein | Posted in Uncategorized | Tagged , , , , , | Comments (2)