The Genomics of Bipolar Disorder


Getting a handle on bipolar disorder is like riding a roller coaster with both patients and physicians — all hollering for stability. There is no diagnostic test to confirm bipolar disorder, and choosing the optimal drug therapy is a frustrating odyssey of trial and error. Manic episodes of overly excited states can quickly slide into states of deep depression. And some antidepressants, while effective in one individual, can trigger new rounds of uncontrollable mania in another.

Photo of Mark Frye, M.D.

Mark Frye, M.D., combines basic and clinical research with psychiatric practice and his new role as department chair.

Mayo Clinic psychiatry researchers are investigating ways to end the roller coaster ride, or at least to eliminate some of its rushes and surges. Mark Frye, M.D., is using genotyping and brain scans in research to hopefully one day match the genetic profile of newly diagnosed patients with the most effective and least harmful drug to treat bipolar disorder.

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For journalists seeking interviews on Bipolar Disorder, please contact Rebecca Eisenman at 507-284-5005.

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2 Responses to The Genomics of Bipolar Disorder

  1. Pingback: Mayo Clinic in the News Weekly Highlights | Mayo Clinic In The News

  2. William says:

    I think that medication is the best way to cope with bipolar disorder but it sad to know that these medications are very strong and harmful. I also think that it is too expensive. I can’t afford those medications because we are poor that is why I am trying to help my kid by giving her a healthy and happy lifestyle, this is the least I can do for her for now.

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