A Mayo Clinic study published in the January issue of Archives of Neurology found that moderate physical activity performed in midlife or later appears to be associated with a reduced risk of mild cognitive impairment. Mild cognitive impairment (MCI) is a transitional state between normal aging and the earliest features of Alzheimer’s disease.
Portions of this study were first presented at an American Academy of Neurology Annual Meeting.
Yonas Geda, M.D., a Mayo Clinic neuropsychiatrist, and his colleagues studied 1,324 individuals without dementia who were part of the Mayo Clinic Study of Aging. Participants completed a physical exercise questionairre between 2006 and 2008 and were assessed by an expert consensus panel and classified as having normal cognition or mild cognitive impairment. A total of 198 participants were determined to have mild cognitive impairment. Midlife moderate exercise (brisk walking, aerobics, yoga, strength training or swimming) was associated with a 39 percent reduction in the odds of developing the condition. Additionally, moderate exercise in late life was associated with a 32 percent reduction.
According to Dr. Geda, physical exercise may protect against mild cognitive impairment via the production of nerve-protecting compounds, greater blood flow to the brain, improved development and survival of neurons and the decreased risk of heart and blood vessel diseases. Or, he explains, a second possibility is that physical exercise may simply be a marker for a healthy lifestyle.
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